Cephalexin. Indications and benefits

What is cephalexin

cephalexin tabletsCephalexin belongs to a class of antibiotics called cephalosporins. Its action prevents bacteria cell wall synthesis whereby the bacteria are killed. The antibiotic is active against wide range of bacterial strains.

Indications

Cephalexin used for combating infections caused by bacteria sensitive to the drug. The drug is used most often to fight infection of the urinary tract and respiratory tract. It is a semi-synthetic cephalosporin antibiotic, belongs to the first generation of these antibiotics. Cephalexin is intended for oral use. It works by inhibiting bacterial cell wall synthesis, which prevents the multiplication of bacterial cells. Due to the chemical structure is considered to be cephalexin is beta-lactam antibiotics, whose common feature is the presence in the molecule of the beta-lactam ring. This structure is sensitive to the action of enzymes, so-called. beta-lactamases produced by some bacteria. Beta-lactamase present in bacterial cells, and may cause degradation and inactivation of the antibiotic particles are one of the causes of bacterial resistance to antibiotics. Cephalexin, like other first generation cephalosporins has a relatively low resistance to beta-lactamases. Used to treat infections of the respiratory tract, urinary and soft tissue.

The advantages of this drug is a broad spectrum of antimicrobial activity, including aerobic and anaerobic pathogens, stability to the action of β- lactamases of staphylococci, enterobacteria and some anaerobes (fuzobakterii, Bacteroides, prevotell) . However, amoxicillin/clavulanate inactive against P.aeruginosa. In the case of microbiologically confirmed Pseudomonas etiology is necessary to use local (3 % acetic acid, ciprofloxacin) and systemic medications (azlocillin, piperacillin, ticarcillin, ceftazidime, ceftazidime, cefepime, aztreonam, ciprofloxacin). All of these AMPs is desirable to use in combination with aminoglycosides (netilmicin, amikacin). Drugs used in large doses, duration of therapy should be 2 weeks (minimum) to 6 weeks (except aminoglycosides, which impose no more than 7-14 days).

Benefits of cephalexin

Cephalexin advantage is that it has not resistant those microorganisms that have developed immunity to the antimicrobial penicillin. Due to this, cephalexin used successfully in the case of protracted tracheitis, bronchitis, sore throats and tonsillitis. A significant drawback of cephalexin – its inability to overcome brain barrier and penetrate the lining of the brain. This eliminates the possibility of its use in the treatment of generalized sepsis, encephalitis and meningitis of any etiology.

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